12 August 2021
Sign up to our newsletterWant more news like this? Sign up to our newsletter.

Medical glue stops bleeding in seconds

Mayo Clinic researchers and colleagues at Massachusetts Institute of Technology (MIT) have developed a rapid-sealing paste that can stop bleeding organs independent of clotting. The details are published in Nature Biomedical Engineering (see link below).

The inspiration for this paste? Barnacles.

Barnacles are those sea animals that adhere to rocks, the bottom of ships and large fish with the aim of staying in place despite wet conditions and variable surfaces. They're successful because they exude a type of oil matrix that cleans the surface and repels moisture. Then they follow up with a protein that cross-links them with the molecules of the surface. That two-step process is what happens when the sealing paste is applied to organs or tissues.

Historically, surgeons would use a type of material that would speed up coagulation and form a clot to stop the bleeding. In the fastest cases, that would still take several minutes. In preclinical studies, this research team has shown the paste to stop bleeding in as little as 15 seconds, even before clotting has begun.

"Our data show how the paste achieves rapid haemostasis in a coagulation-independent fashion. The resulting tissue seal can withstand even high arterial pressures," says Christoph Nabzdyk, a Mayo Clinic cardiac anaesthesiologist and critical care physician. "We think the paste may be useful in stemming severe bleeding, including in internal organs, and in patients with clotting disorders or on blood thinners. This might become useful for the care of military and civilian trauma victims." Nabzdyk is co-senior lead author of the study.

The paste consists of an injectable material that consists of a water-repelling oil matrix and bioadhesive microparticles. It's the microparticles that link to each other and the surface of the tissue after the oil has provided a clean place to connect. The biomaterial slowly resorbs over a period of weeks.

The research was supported by MIT's Deshpande Center, National Institutes of Health, National Science Foundation, Army Research Office, The Zoll Foundation, and the Samsung Scholarship. The technology is protected by a shared patent between MIT and Mayo Clinic.

Co-authors are Hyunwoo Yuk, Jingjing Wu, Xinyu Mao, Claudia Varela, Ellen Roche and Xuanhe Zhao of MIT, and Tiffany Sarrafian Griffiths and Leigh Griffiths of Mayo Clinic.

FAST magazine

Related Websites


Related Companies

Mayo Clinic

Similar Articles

MAB/Additive International

MA Business, part of the Mark Allen Group, and publisher of FAST magazine, has partnered with the Centre for Additive Manufacturing (CfAM) at the University of Nottingham and ...

Stainless-steel enclosures

BCL Enclosures’ new BEDSS stainless steel series of lockable, solid door enclosures are designed to provide high-quality, secure, cost-effective protection for specialist and ...

New compressor valve steel

Swedish metals producer Sandvik has launched a compressor valve steel, Freeflex.

Technical glass introduction

Goodfellow introduces the uses and flexibility of technical glass.

‘Hyper glue’

With many of the products we use every day held together by adhesives, Canadian researchers hope to make everything from protective clothing to medical implants and residential ...

Precision in small doses

Here Paul Whitehead, key account manager at adhesives specialist Intertronics, shares his thoughts on the precise metering, mixing and dispensing of small amounts of two-part ...

Engineered wave spring

Medical devices must be dependable down to their smallest components, such as wave springs and circlips so they can perform critical functions every time.

Dispensing Made Easy with the

Fisnar, leading manufacturer of fluid dispensing equipment, is pleased to announce the launch of its DC50 Digital Dispense Controller. A new addition to their popular DC series ...

Staytite Masks & Consumables

Staytite’s 3 ply disposable masks offer you and your team the perfect protection during these uncertain and difficult times. With its fibre glass free layer and comfortable ear ...